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Siren, L.L.C.
investisseur institutionnel · portefeuille $4.94 Md · 119 positions · rapport au 30.06.2026
Positions en Actions rapport pour 30.06.2026, déposé le 13.08.2026; modification — par rapport à 31.03.2026 · 125
| Société | Actions | Valeur | % du portefeuille | Variation sur le Trimestre |
|---|---|---|---|---|
| Scholar Rock Holding Corp US:SRRK | 9 575 013 | $527 M | 10.69% | −1 250 000 |
| Kymera Therapeutics Inc US:KYMR | 2 935 830 | $337 M | 6.83% | −251 000 |
| Erasca Inc US:ERAS | 11 397 781 | $209 M | 4.24% | +153 535 |
| Veradermics, Incorporated US:MANE | 1 655 374 | $204 M | 4.13% | +150 000 |
| Tango Therapeutics, Inc. US:TNGX | 6 179 364 | $193 M | 3.92% | +522 259 |
| Revolution Medicines, Inc. US:RVMD | 900 000 | $169 M | 3.42% | −210 980 |
| Bicara Therapeutics Inc. US:BCAX | 5 602 970 | $166 M | 3.38% | −200 000 |
| Arrowhead Pharmaceuticals In… US:ARWR | 1 715 476 | $140 M | 2.84% | +100 000 |
| Beone Medicines US:ONC · certificat de dépôt | 465 000 | $133 M | 2.69% | — |
| Edgewise Therapeutics Inc US:EWTX | 3 184 629 | $129 M | 2.63% | −1 245 634 |
| Rhythm Pharmaceuticals Inc US:RYTM | 1 136 275 | $126 M | 2.56% | +410 764 |
| Lexicon Pharmaceuticals Inc US:LXRX | 44 303 518 | $106 M | 2.16% | — |
| Enliven Therapeutics Inc. US:ELVN | 1 774 411 | $90.1 M | 1.83% | +1 028 185 |
| Spyre Therapeutics Inc. US:SYRE | 968 598 | $86.0 M | 1.75% | +150 000 |
| Parabilis Medicines, Inc. US:PBLS | 2 992 259 | $81.9 M | 1.66% | nouvelle |
| Xenon Pharmaceuticals Inc US:XENE | 1 318 564 | $79.6 M | 1.62% | — |
| Solid Biosciences LLC US:SLDB | 7 690 405 | $76.8 M | 1.56% | — |
| ABIVAX US:ABVX · certificat de dépôt | 576 000 | $76.8 M | 1.56% | nouvelle |
| Hemab Therapeutics Holdings,… US:COAG | 2 086 834 | $76.6 M | 1.56% | nouvelle |
| Arcus Biosciences Inc US:RCUS | 2 420 430 | $74.6 M | 1.51% | −586 647 |
| Cogent Biosciences Inc US:COGT | 1 859 279 | $72.0 M | 1.46% | +150 000 |
| Relay Therapeutics Inc US:RLAY | 3 650 000 | $68.3 M | 1.39% | nouvelle |
| Taysha Gene Therapies Inc US:TSHA | 9 846 579 | $67.1 M | 1.36% | +1 016 666 |
| Definium Therapeutics, Inc. US:DFTX | 1 419 493 | $66.8 M | 1.36% | +500 000 |
| Stoke Therapeutics, Inc. US:STOK | 1 995 347 | $65.3 M | 1.33% | — |
| Disc Medicine Inc. US:IRON | 888 401 | $65.0 M | 1.32% | −100 000 |
| Cytokinetics Inc US:CYTK | 758 952 | $64.7 M | 1.31% | +145 000 |
| Septerna, Inc. US:SEPN | 1 900 000 | $63.6 M | 1.29% | −100 000 |
| Olema Pharmaceuticals Inc US:OLMA | 4 856 949 | $60.8 M | 1.23% | +100 000 |
| Crinetics Pharmaceuticals In… CUSIP 22663K107 | 1 420 788 | $53.2 M | 1.08% | −482 848 |
| Kailera Therapeutics, Inc. US:KLRA | 2 214 286 | $48.8 M | 0.99% | nouvelle |
| Dyne Therapeutics Inc US:DYN | 2 129 125 | $47.3 M | 0.96% | −100 000 |
| Structure Therapeutics Inc.… US:GPCR · certificat de dépôt | 872 967 | $46.9 M | 0.95% | −455 731 |
| Taboola.com Ltd CUSIP M8744T106 | 8 423 410 | $42.1 M | 0.86% | −1 546 085 |
| Palvella Therapeutics, Inc US:PVLA | 257 485 | $39.3 M | 0.80% | — |
| Silence Therapeutics PLC US:SLN · certificat de dépôt | 3 311 438 | $36.4 M | 0.74% | +400 000 |
| Denali Therapeutics Inc US:DNLI | 1 396 513 | $35.9 M | 0.73% | — |
| Remitly Global Inc US:RELY | 1 543 271 | $34.6 M | 0.70% | — |
| Cullinan Therapeutics, Inc. US:CGEM | 1 893 410 | $34.5 M | 0.70% | +700 000 |
| Capital One Financial Corpor… US:COF | 171 615 | $34.4 M | 0.70% | nouvelle |
| Trevi Therapeutics Inc US:TRVI | 1 786 867 | $33.3 M | 0.68% | — |
| Oric Pharmaceuticals, Inc. US:ORIC | 2 998 192 | $32.5 M | 0.66% | — |
| Alphabet Inc. US:GOOGL | 90 000 | $32.2 M | 0.65% | +24 297 |
| DBV Technologies US:DBVT · certificat de dépôt | 1 857 362 | $30.5 M | 0.62% | — |
| Absci Corp US:ABSI | 2 474 764 | $28.7 M | 0.58% | +674 764 |
| Sionna Therapeutics, Inc. US:SION | 610 515 | $26.9 M | 0.55% | +310 515 |
| Rapport Therapeutics, Inc. US:RAPP | 641 469 | $26.7 M | 0.54% | — |
| Amylyx Pharmaceuticals Inc US:AMLX | 1 480 586 | $26.6 M | 0.54% | +250 586 |
| Annexon, Inc. US:ANNX | 4 458 646 | $25.5 M | 0.52% | +500 000 |
| Monopar Therapeutics Inc US:MNPR | 270 118 | $25.0 M | 0.51% | — |
| Oruka Therapeutics, Inc. US:ORKA | 250 000 | $23.8 M | 0.48% | nouvelle |
| Seaport Therapeutics, Inc. US:SPTX | 1 095 316 | $23.8 M | 0.48% | nouvelle |
| Damora Therapeutics Inc CUSIP 36322Q206 | 900 000 | $23.4 M | 0.48% | — |
| Tyra Biosciences Inc US:TYRA | 725 000 | $23.2 M | 0.47% | nouvelle |
| Zura Bio Ltd CUSIP G9TY5A101 | 3 734 866 | $22.0 M | 0.45% | — |
| Taiwan Semiconductor Manufac… US:TSM · certificat de dépôt | 44 700 | $21.3 M | 0.43% | +2 500 |
| NVIDIA Corporation US:NVDA | 95 000 | $19.0 M | 0.39% | +5 915 |
| Rezolute, Inc. US:RZLT | 3 328 287 | $17.3 M | 0.35% | — |
| MapLight Therapeutics, Inc. US:MPLT | 450 000 | $16.1 M | 0.33% | — |
| Neumora Therapeutics, Inc. US:NMRA | 8 497 822 | $14.4 M | 0.29% | — |
| Nebius Group NV CUSIP N97284108 | 52 000 | $14.4 M | 0.29% | −61 614 |
| Microsoft Corporation US:MSFT | 37 500 | $14.0 M | 0.28% | −3 880 |
| CytomX Therapeutics Inc US:CTMX | 3 457 711 | $13.0 M | 0.26% | — |
| Generate Biomedicines, Inc. US:GENB | 736 104 | $12.4 M | 0.25% | — |
| Inhibikase Therapeutics Inc US:IKT | 5 850 000 | $11.9 M | 0.24% | — |
| Adagene Inc. US:ADAG · certificat de dépôt | 2 666 666 | $11.2 M | 0.23% | nouvelle |
| enGene Therapeutics Inc. US:ENGN | 6 256 662 | $10.8 M | 0.22% | nouvelle |
| Whitehawk Therapeutics, Inc. US:WHWK | 2 337 102 | $10.7 M | 0.22% | +255 102 |
| Datadog, Inc. US:DDOG | 40 000 | $10.4 M | 0.21% | −14 300 |
| ServiceNow Inc US:NOW | 100 000 | $9.93 M | 0.20% | +12 910 |
| Broadcom Inc. US:AVGO | 25 000 | $9.44 M | 0.19% | +10 000 |
| IONQ Inc US:IONQ | 170 000 | $9.05 M | 0.18% | — |
| Jfrog Ltd CUSIP M6191J100 | 95 500 | $8.68 M | 0.18% | −33 316 |
| Oculis Holding AG CUSIP H5870P102 | 625 000 | $8.67 M | 0.18% | nouvelle |
| IREN Ltd CUSIP Q4982L109 | 175 000 | $8.00 M | 0.16% | +131 900 |
| Amazon.com, Inc. US:AMZN | 32 500 | $7.75 M | 0.16% | −14 141 |
| CrowdStrike Holdings, Inc. US:CRWD | 10 000 | $7.63 M | 0.15% | −13 070 |
| Design Therapeutics Inc US:DSGN | 523 212 | $7.57 M | 0.15% | nouvelle |
| PDD Holdings Inc. US:PDD · certificat de dépôt | 95 000 | $7.25 M | 0.15% | +11 599 |
| Satellos Bioscience Inc. US:MSLE | 892 074 | $6.94 M | 0.14% | — |
| Dynatrace, Inc. US:DT | 155 000 | $6.81 M | 0.14% | +5 000 |
| Tenax Therapeutics Inc US:TENX | 427 141 | $6.21 M | 0.13% | — |
| vTv Therapeutics Inc US:VTVT | 163 000 | $6.14 M | 0.12% | — |
| Eloxx Pharmaceuticals, Inc. US:ELOX | 400 000 | $5.55 M | 0.11% | nouvelle |
| AgomAb Therapeutics NV Ameri… US:AGMB · certificat de dépôt | 411 250 | $5.34 M | 0.11% | — |
| Alibaba Group Holding Limite… US:BABA · certificat de dépôt | 50 000 | $4.80 M | 0.10% | nouvelle |
| Korro Bio, Inc. US:KRRO | 347 718 | $4.58 M | 0.09% | — |
| Cellebrite DI Ltd CUSIP M2197Q107 | 311 544 | $4.55 M | 0.09% | — |
| Invivyd Inc. US:IVVD | 5 000 000 | $4.36 M | 0.09% | +1 000 000 |
| Ouster, Inc. US:OUST | 67 500 | $4.22 M | 0.09% | nouvelle |
| Palisade Bio Inc US:PALI | 2 000 000 | $4.18 M | 0.08% | nouvelle |
| Aeva Technologies, Inc. US:AEVA | 145 459 | $4.18 M | 0.08% | +35 459 |
| Seer Inc US:SEER | 2 458 673 | $4.08 M | 0.08% | — |
| NovaBridge Biosciences US:NBP · certificat de dépôt | 2 004 739 | $3.91 M | 0.08% | −995 261 |
| Gitlab Inc US:GTLB | 125 000 | $3.82 M | 0.08% | +25 000 |
| Odyssey Therapeutics, Inc. US:ODTX | 200 000 | $3.74 M | 0.08% | nouvelle |
| Foghorn Therapeutics Inc US:FHTX | 720 720 | $3.52 M | 0.07% | — |
| Agenus Inc US:AGEN | 1 064 250 | $3.26 M | 0.07% | — |
| monday.com Ltd CUSIP M7S64H106 | 42 500 | $3.08 M | 0.06% | +17 500 |
| Zoetis Inc US:ZTS | 35 000 | $2.52 M | 0.05% | nouvelle |
| Workiva Inc US:WK | 45 000 | $2.18 M | 0.04% | −47 500 |
| Netflix Inc US:NFLX | 25 000 | $1.78 M | 0.04% | nouvelle |
| Kalaris Therapeutics, Inc. US:KLRS | 435 798 | $1.77 M | 0.04% | — |
| Quantinuum Inc. Class A US:QNT | 20 000 | $1.63 M | 0.03% | nouvelle |
| Rani Therapeutics Holdings I… US:RANI | 2 000 000 | $1.52 M | 0.03% | — |
| Tesla, Inc. US:TSLA | 3 500 | $1.47 M | 0.03% | −18 000 |
| Ke Holdings Inc US:BEKE · certificat de dépôt | 100 000 | $1.45 M | 0.03% | — |
| Entera Bio Ltd CUSIP M40527109 | 736 457 | $1.30 M | 0.03% | nouvelle |
| Medline Inc. Class A US:MDLN | 25 000 | $986 k | 0.02% | — |
| Lumentum Holdings Inc. US:LITE | 1 055 | $905 k | 0.02% | nouvelle |
| Figma, Inc. US:FIG | 50 000 | $905 k | 0.02% | — |
| Gossamer Bio Inc CUSIP 38341P102 | 5 208 968 | $857 k | 0.02% | — |
| Fox Corp US:FOXA | 10 000 | $522 k | 0.01% | nouvelle |
| AT&T Inc. US:T | 25 000 | $518 k | 0.01% | nouvelle |
| Nu Holdings Ltd. CUSIP G6683N103 | 25 000 | $334 k | 0.01% | — |
| Bicycle Therapeutics Ltd US:BCYC · certificat de dépôt | 0 (était 1 560 882) | — | — | vendue |
| Centessa Pharmaceuticals PLC CUSIP 152309100 | 0 (était 1 053 464) | — | — | vendue |
| enGene Holdings Inc CUSIP 29286M105 | 0 (était 5 253 159) | — | — | vendue |
| Forgent Power Solutions, Inc… US:FPS | 0 (était 100 000) | — | — | vendue |
| Fulcrum Therapeutics Inc US:FULC | 0 (était 2 350 000) | — | — | vendue |
| Micron Technology Inc US:MU | 0 (était 6 000) | — | — | vendue |
| Primo Brands Corporation US:PRMB | 0 (était 50 000) | — | — | vendue |
| Amer Sports Inc CUSIP G0260P102 | 0 (était 50 000) | — | — | vendue |
| Uniqure NV CUSIP N90064101 | 0 (était 1 000 000) | — | — | vendue |
| WAVE Life Sciences Ltd CUSIP Y95308105 | 0 (était 2 450 000) | — | — | vendue |
Dans les entreprises de notre base de données 4
| Société | Participation | Actions | Date du Rapport |
|---|---|---|---|
| enGene Therapeutics Inc. | 9.34% | 6 256 662 | 2026-06-30 |
| Silence Therapeutics PLC | 5.5% | 3 311 438 | 2026-06-30 |
| Satellos Bioscience Inc. | 4.2% | 892 074 | 2026-06-30 |
| DBV Technologies | 2.95% | 1 857 362 | 2026-06-30 |
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