| SKORPEN EVAN (Director) Insider | — | — | — | 1 | — |
| Legal and General Group Employ… Insider | — | — | — | 1 | — |
| SWANSON CHAD PH.D. (Officer) Insider | — | — | — | 1 | — |
| Karantoni (Annette) (Divisiona… Insider | — | — | — | 1 | — |
| Vulpes Life Science Fund Insider | — | — | — | 1 | — |
| Manning & Napier Fund, Inc.-Ov… Fonds | — | — | — | 1 | 0.37% |
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| DAS PARAMITA (Officer) Insider | — | — | — | 1 | — |
| CATAPANO JOSEPH RONALD (Office… Insider | — | — | — | 1 | — |
| AIYAR PRIYA (Officer) Insider | — | — | — | 1 | — |
| Panchal (Abhishek N) (UNREPORT… Insider | — | — | — | 1 | — |
| Alphamark Advisors, Llc institutioneller Anleger | — | — | — | 1 | 0.01% |
| BOERNER CHRISTOPHER S (Chief E… Insider | — | — | — | 1 | — |
| ADCOCK MARY ELLEN (Officer) Insider | — | — | — | 1 | — |
| KALTER BRAD S (General Counsel… Insider | — | — | — | 1 | — |
| LIPESKY SCOTT D (Chief Operati… Insider | — | — | — | 1 | — |
| TENNENBAUM ROSS J (Chief Finan… Insider | — | — | — | 1 | — |
| LAPPETITO SCOTT M (Chief Finan… Insider | — | — | — | 1 | — |
| HILL ELLIOTT (Chief Executive… Insider | — | — | — | 1 | — |
| HEIDEMAN ROBERT JAMES (Chief T… Insider | — | — | — | 1 | — |
| KEENE RUTH ANN (Officer) Insider | — | — | — | 1 | — |
| ROWGHANI ALI (Director) Insider | — | — | — | 1 | — |
| JNL Series Trust-JNL Multi-Man… Fonds | — | — | — | 1 | 1.19% |
| RISCH THERACE M (Officer) Insider | — | — | — | 1 | — |
| CALKINS MATTHEW W (Chief Execu… Insider | — | — | — | 1 | — |
| HARTUNG JOHN R (President) Insider | — | — | — | 1 | — |
| NORDSTROM PHYLLIS B (Chief Fin… Insider | — | — | — | 1 | — |
| FILSON BRANDON (Chief Financia… Insider | — | — | — | 1 | — |
| ARORA ANIL (Director) Insider | — | — | — | 1 | — |
| Watkins (Alison Mary) (Indepen… Insider | — | — | — | 1 | — |
| Gunn (Stephen) (Director of Is… Insider | — | — | — | 1 | — |
